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PROTOPORPHYRINOGEN OXIDASE
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DeCS
Descriptor
English
:
Protoporphyrinogen Oxidase
Descriptor
Spanish
:
Protoporfirinógeno-Oxidasa
Descriptor
Portuguese
:
Protoporfirinogênio Oxidase
Tree Number:
D08.811.682.660.600
D12.776.543.697
Definition
English
:
A membrane-bound flavoenzyme that catalyzes the oxygen-dependent aromatization of protoporphyrinogen IX (Protogen) to protoporphyrin IX (Proto IX). It is the last enzyme of the common branch of the
HEME
and
CHLOROPHYLL
pathways in
plants
, and is the molecular target of diphenyl ether-type
herbicides
. VARIEGATE PORPHYRIA is an autosomal dominant disorder associated with deficiency of
protoporphyrinogen oxidase.
Entry Combination - descr/qualif
English
:
Protoporphyrinogen Oxidase
/
deficiency
use
Porphyria, Variegate
History Note
English
:
2006(1975)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
50629
Unique Identifier:
D050768
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS